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Troponin I

by ivette_marrero — last modified February 09, 2010 10:10 PM


UNC Hospitals
McLendon Clinical Laboratories
101 Manning Drive
Chapel Hill, NC 27514

 

 

 

Tube Type 
gold top tube
Test ID TRPNI
Test Number 1733
SMS Browse TROPONIN I, QUANTITATIVE
CPT Code(s) 84484
Group/Individual Test Individual 
Laboratory Core
Tube Station Routine: 30
STAT: 888
SpecimenRoutine:4 mL Blood / Serum Separator / Gold Top Tube; See Important Comments
 micro:1 mL Blood / Serum Separator / Gold Top Tube; See Important Comments
AvailabilityRoutine:24 hrs/day
 STAT:Yes
   
Turnaround Time Routine: 2 hours
STAT: 1 hour
Reference RangeNormal:0.00-0.034 ng/mL
   
Comments

The Troponin I (TnI, Ortho Clinical Diagnostics) assay is specific to myocardium and does NOT cross react with the skeletal muscle Troponin I isotypes.    

Detectable levels of Troponin I are seen within 4-6 hours following an acute myocardial infarction (AMI) and remain elevated for
7-14 days. Because Troponin I reflects myocardial cell damage, conditions other than AMI will result in increases in TnI concentrations. Such include sepsis, congestive heart failure, hypertension with left ventricular hypertrophy, hemodynamic compromise, myocarditis, mechanical injury including surgery, defibrillation, and cardiac toxins. This means we expect to see low levels in patients who have had myocardial injury but not necessarily an AMI. For AMI, one should look for increasing concentrations across serial samples.   For those patients with low or stable levels, remember that TnI has long been shown to be a good risk assessment marker for evaluating patients with unstable angina and acute coronary syndrome. 

Conversion formulae cannot be used to convert TnT to TnI because of the unique release characteristics and complicated metabolism of each. TnT does not equal TnI.   

Reference range: 0.0-0.034 ng/mL. The 99th  percentile upper reference limit is 0.034 ng/mL.

Hemolysis increases Troponin I values due to an analytical interference (TnI is not in erythrocytes).

 

 

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Troponin I

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